Sex differences in hyperphagia and body weight gains following goldthioglucose-induced hypothalamic lesions in mice
نویسندگان
چکیده
منابع مشابه
Sex differences in hyperphagia and body weight gains following goldthioglucose-induced hypothalamic lesions in mice*
Hypothalamic damage was induced in age-matched male and female albino mice by goldthioglucose injection, and their food consumption and body weight were compared over the following 60-day period. Sex differences in food consumption were also investigated as a function of palatability of food. Results show no significant sex differences in food consumption, although marked sex differences in bod...
متن کاملSex differences in body weight gains following amygdaloid lesions in rats.
Lesions of the most posterodorsal aspects of the amygdala resulted in equal weight gains (mean = 58 g) in male and female rats during a 22-day observation period. However, the absolute weight gains in the first 5 days after lesions were greater in females (+41.4 g) than in males (+18.8 g), as were the longer-term gains relative to their respective control groups. In a second study with female r...
متن کاملThe Effect of Hyperglycemia on Hypothalamic Gold Uptake and Hyperphagia in Goldthioglucose-treated Mice
The accumulation of gold in the hypothalamus and the development of hyperphagia and obesity were studied in mice given a single intravenous injection of goldthioglucose at various levels of blood glucose concentration. It was found that the glucose concentration prevailing at the time of goldthioglucose injection was correlated directly with the level of free and bound goldthioglucose in the bl...
متن کاملHypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats.
Excessive weight gain is a major metabolic side effect of second-generation antipsychotics (SGAs) in the treatment of schizophrenia. Ghrelin is an orexigenic hormone secreted mainly from the stomach, which can induce weight gain and hyperphagia through regulating neuropeptides at the hypothalamus. Accumulating evidence implicates a relationship between ghrelin signalling and SGA-induced hyperph...
متن کاملOlanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation
The success of antipsychotic drug treatment in patients with schizophrenia is limited by the propensity of these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine and clozapine. However, the molecular mechanisms involved in antipsychotic-induced hyperphagia remain unclear. Here, we investigate the effect of olanzapine administration o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Physiological Psychology
سال: 1973
ISSN: 0090-5046
DOI: 10.3758/bf03326912